The PoliUniBus project is built upon the expertise already established in UniBus project, PoliUniBus has proposed the conception of a collaborative cloud-based platform that implements a new challenge-led methodology to support HEIs to link with businesses across the Europe. The PoliUniBus methodology & platform supported a use of ‘challenges’ led by policy-makers to set conditions for AGILE innovation. Engagement across Universities and Industry allowed companies to manage & implement the complex innovation processes by taking advantage of universities’ research and technological knowledge and expertise in a systematic way, by enabling an open multi-agent focused innovation (i.e. university/business focused innovation).